Program and book of abstracts 1st conference

1 st Conference of European Academy for Molecular Hydrogen Research in Biomedicine “Hydrogen for Biomedicine“

Zhao Lin

Dr. Lin Zhao received her Bachelor's degree, Master’s degree and PhD from Xi’an Jiaotong Unviersity and was trained as a post-graduate fellow at YALE University, USA from 2010 to 2012. She’s been working as a faculty member in Xi’an Jiaotong Unviersity and currently is an associate professor. Dr. Zhao’s research interests include understanding how environmental and nutritional factors modulates redox signaling andmitochondrial homeostasis from the perspective of nutrient/stress-sensing and post-translational modifications, and exploring the efficacies of natural compounds and derivatives in regulating mitochondrial dynamics, metabolism and redox homeostasis for prevention and treatment of age associated and metabolic disorders. Dr. Zhao has published 14 papers on peer reviewed international journals, and these papers have got more than 500 citations with a H-index of 10. GUT-DERIVED MOLECULAR HYDROGEN: IMPLICATIONS IN METABOLIC SYNDROME Lin Zhao Xi’an Jiaotong University, Xi’an, China E-mail: zhaolin2015@xjtu.edu.cn Molecular hydrogen, the smallest molecule found in nature, has long been deemed as inactive for the human body. However, recently a robust wave of emerging reports involving both laboratory animal models and clinical studies demonstrated the versatile efficacies of exogenously supplemented molecular hydrogen in a wide spectrum of diseases, thereby bringing the biological effects of molecular hydrogen into light, which encompasses selective antioxidation, anti-inflammation, anti-apoptosis, regulation of gene expression and signal transduction, etc. molecular hydrogen holds great potential for medical prevention and treatment of multiple diseases, such as obesity, diabetes, cardiovascular diseases, many types of cancer, various ischemic injuries including stroke, inflammatory diseases, neurodegenerative diseases, etc. Currently, approaches for hydrogen exposure include intake of hydrogen-rich water, inhalation of hydrogen gas, hydrogen bath, ingestion of hydrogen solid carriers. Nevertheless, what is currently less appreciated that hydrogen molecules in fact can be produced in considerable amount by fermentation in the anaerobic ecosystem of the gut. Healthy human gut microbiome yields considerable amount of hydrogen gas constantly by utilizing undigested food components, mostly fibers and carbohydrates. These gut-derived hydrogen molecules should diffuse easily across the gut barrier and play a role in modulating pathophysiological processes of the host. We employed L-arabinose as an inducer of gut-derived hydrogen production in mice and it improved multiple metabolic parameters of mice on high-fat-diet, and blocking gut-derived hydrogen production by antibiotics abolished the amelioration of insulin resistance by L-arabinose. Further studies are urgently needed to elaborate the role of gut-derived molecular hydrogen is metabolic syndrome and in health and diseases in general.

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