Program and book of abstracts 1st conference

October 17 th – 20 th , 2022, Congress Centre of Slovak Academy of Sciences, Smolenice castle, Slovakia

Xie Keliang

Dr. Keliang Xie is a Professor of Tianjin Medical University working as a Director of ICU in Tianjin Medical University General Hospital. Currently, his research interests include sepsis, molecular hydrogen and mitochondria. In recent five years, he has published 63 SCI papres, 26 of which are as the first, co-first and corresponding author, and was rewarded as ‘Taishan Scholars and young experts’. At the same time, he served as a reviewer of several SCI journals. PERSPECTIVE OF MOLECULAR HYDROGEN IN THE TREATMENT OF SEPSIS Keliang Xie 1,2 1 Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China; 2 Translational Research Institute of Intensive Care Medicine, College of Anesthesiology, Weifang Medical University, Weifang 261053, Shandong Province, P.R. China. BACKGROUND: Sepsis is the main cause of death in critically ill patients with no effective treatment. Sepsis is life- threatening organ dysfunction due to a dysregulated host response to infection. As a novel medical gas, molecular hydrogen (H2) has a therapeutic effect on many diseases, such as sepsis. H2 treatment exerts multiple biological effects, which can effectively improve multiple organ injuries caused by sepsis. However, the underlying molecular mechanisms of hydrogen involved in the treatment of sepsis remain elusive, which are likely related to anti-inflammation, anti-oxidation, anti-apoptosis, regulation of autophagy and multiple signaling pathways. OBJECTIVES: This review can help better understand the progress of hydrogen in the treatment of sepsis, and provide a theoretical basis for the clinical application of hydrogen therapy in sepsis in the future. CONCLUSION: Hydrogen may play a beneficial role via anti-inflammation, anti-oxidation, anti-apoptosis and autophagy regulation. Besides, hydrogen also has a potential therapeutic effect on a variety of diseases. Although the results of numbers of scientific studies showed the positive role of hydrogen, its pathophysiological process and mechanisms need to be further studied to make hydrogen better for clinical use. This study was supported by a grant from the Natural Science Foundation of Tianjin (17JCYBJC24800 to Keliang Xie); Science and Technology Support Key Program Affiliated to the Key Re- search and Development Plan of Tianjin Science and Technology Project (18YFZCSY00560 to Keliang Xie); National Natural Sci- ence Foundation of China (81772043, 81971879 to Keliang Xie), Beijing, China.

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