Program and book of abstracts 1st conference

1 st Conference of European Academy for Molecular Hydrogen Research in Biomedicine “Hydrogen for Biomedicine“

Pechanova Olga

Olga Pechanova is a director of Centre of Experimental Medicine, Slovak Academy of Sciences (CEMSAS) and president of International Society of Pathophysiology. She has 30-year experiences in the cardiovascular research and development of medications aimed to treat hypertension and cardiovascular consequences. Her study is focused on the analysis of imbalance in the production of nitric oxide (NO) and reactive oxygen species (ROS) in different models of cardiovascular and metabolic disorders. Olga Pechanova has authored about 150 impacted manuscripts, 1 patent, and she is co-author of several monographs, H-index 39. Olga Pechanova also teaches at Faculty of Natural Sciences and Medical

Faculty, Comenius University, Bratislava. NITRIC OXIDE: FROM THE BENEFICAL EFFECTS OF THE SOLO MOLECULE TO COMBINATION THERAPY WITH MOLECULAR HYDROGEN Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia BACKGROUND: As a well-known gasotransmitter along with hydrogen sulfide and carbon monoxide, nitric oxide (NO) has earned repute as a potent vasodilator also known as endothelium-derived vasorelaxant factor. NO has been studied in greater detail, from its synthesis and mechanism of action to its physiologic, pathologic, and pharmacologic roles in different disease states. Different animal models have been applied to investigate the beneficial effects of NO as an antihypertensive, renoprotective, and antihypertrophic agent. NO and its interaction with different systems like the renin–angiotensin system, sympathetic nervous system, and other gaseous transmitters like hydrogen sulfide are also well studied. However, links that appear to exist between the molecular hydrogen and NO systems remain to be fully explored. OBJECTIVES: This study aimed to make an overview of possible beneficial effects of molecular hydrogen and NO combined therapy in the cardiovascular system.

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