Program and book of abstracts 1st conference

October 17 th – 20 th , 2022, Congress Centre of Slovak Academy of Sciences, Smolenice castle, Slovakia

Ohta Shigeo

Is currently a Professor Emeritus at Nippon Medical University, Tokyo, Japan and a Visiting Professor of Juntendo University, Tokyo, Japan. He gradated from the university of Tokyo in 1974, and received his phD from the university of Tokyo in 1979. He was a professor and Chairperson in Nippon Medical University in 2014-2022. He is the Honorary Presidents of the Japanese Society of Mitochondrial Research and Medicine, the Japanese Biomedical Society for Molecular Biology and International Society for Hydrogen Medicine and Biology. His total publication citations are 15,400 and his h-index is 64. In the field of mitochondrial medicine field, he found a drug for the treatment of mitochondrial disorder and it was approved for the first time in the world in 2019. He discovered the biomedical function of molecular hydrogen and published a historical article in Nature Medicine 2007. This article has been cited 2,200 and 1,500 times byGoogle Scholar and Scopus, respectively. He has recently edited a special issue for HydrogenMedicine and Biology in Current Pharmaceutical Design (2021). DEVELOMPENT OF HYDROGEN MEDICINE AND ITS MISSION FOR THE FUTURE S. Ohta 1,2 1 Nippon Medical University, Tokyo, Japan, 2 Juntendo University, Department of Neurology Medicine, Tokyo Japan Molecular hydrogen (H 2 ) was regarded as a non-functional and biologically inert gas in mammalian cells for a long time. We overturned this old concept by publishing a historical article in Nature Medicine in 2007. An increasing body of research has revealed diverse potential for marked efficacy in various model animals without adverse effects even if acute or chronic diseases. H 2 improves the quality of life for health care, physical andmental labors, sports, and cosmetology for healthy people as well as for patients with various diseases. These studies indicate that H 2 has several characteristics that differ from conventional medicines. Moreover, H 2 is beneficial for not only animals, but also higher plants, promising that H 2 can arise a strong impact on agriculture. There are a variety of ways to ingest H 2 into the body; inhalation of H 2 gas, drinking H 2 dissolved water, and injection of H 2 dissolved saline and so on. Recent studies in pharmacokinetics revealed the pathways of H 2 incorporation in each method. At cellular levels, H 2 exhibits multiple functions through various singling pathways, including anti-oxidation, anti-inflammatory, and anti-allergic effects, stimulation of energy metabolism, and regulation of cell death and autophagy. Since H 2 cannot react with most biological molecules without a catalyst, it is not easy to elucidate all the molecular mechanisms by which H 2 exerts the multiple functions. We provided a model in which H 2 modifies lipid peroxides or oxidized phospholipids in free radical chain reaction, and these modified products function as mediators for signal transductions. In the world’s aging society, hydrogen medicine has potential for overcoming serious and urgent problems such as aging-associated lifestyle-related diseases, post-cardiac arrest, dementia, and advanced cancer. We show here that long-term H 2 inhalation improved patients with Alzheimer’s disease as a disease-modifying therapy. In the future, we wish that these challenges would be generally approved by large-scale randomized clinical trials in patients or the general public to accept the beneficial effects of H 2 .

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