Program and book of abstracts 1st conference

1 st Conference of European Academy for Molecular Hydrogen Research in Biomedicine “Hydrogen for Biomedicine“

Lucas Kurt

Kurt Lucas studied biology in Freiburg, Germany. After his PhD thesis on the tumor markers in 1991 he went to industry. Here he focused on Intellectual Property as well on Merger and Acquisition. In 2010 he became badly ill by a rare allergic disease and suffered from Chronic Fatigue Syndrome. He had to quit his job and studied during one year about 1000 publications. It become clear, that overshooting oxidative stress was a main problem of his allergic disease. So, he decided to treat himself with molecular hydrogen enriched water. In fact, after 8 weeks of daily intake of molecular hydrogen enriched water, he recovered from Chronic Fatigue. Moreover, he discovered a vicious circle of inflammation. Kurt Lucas, together with Michael Maes, a world leading fatigue expert, published these results. Consequently, he got a position as group leader at the Max Planck Institute for Chemistry, Mainz, Germany. His focus is on the molecular processes of inflammation. Whereas pattern recognition receptors, cytokines, DAMPs and reactive oxygen species are subject of his research. In Europe no nutritional supplement for the preparation of a hydrogen releasing tablet is available, that follows the regulations of the European Community. In close cooperation with the department of Pharmacy of the University Mainz, such a tablet was developed. Here Kurt Lucas will report of the various hurdles to obtain a hydrogen tablet formulation, which is suited for an industrial production process. DEVELOPMENT OF AN EFFERVESCENT HYDROGEN GENERATING TABLET Kurt Lucas 1 , Moritz Rosch 2 , Jozef Al-Gousous 3,4 Ulrich Pöschl 1 and Peter Langguth 3 1 Max Planck Institute for Chemistry, Multiphase Chemistry Department, 55128 Mainz, Germany, 2 University Medical Center Hamburg Eppendorf; Hospital Pharmacy; 20246 Hamburg; Germany, 3 InstituteofPharmaceutical andBiomedical Sciences,DepartmentofBiopharmaceuticsand PharmaceuticalTechnology, JohannesGutenbergUniversityMainz,55128Mainz,Germany, 4 Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109, USA. The leading question at the beginning of our researchwas how to obtain hydrogen-enriched water. Besides the commonly used electrolysis, a chemical reaction was the preferred option. A known reaction scheme to produce hydrogen is: metal and acid, which react to molecular hydrogen gas and the respective salt. Among physiologically tolerable metals magnesium seemed to be ideal, since it is not as reactive as sodium or potassium and does not require a strong acidic environment, as iron or zinc would. First choice for the acid were ascorbic acid and citric acid. The solubility of hydrogen in water is 1.6 mg of gas dissolved in 1 liter of water at atmospheric pressure. Accordingly, about 20 mg magnesium is needed to saturate a liter of water. Based on this, the idea was born to formulate an oxidative stable, effervescent hydrogen-generating tablet. The development of such a tablet, which also should be in accordance with the regulations for dietary supplements of the European Community, needs expertise. Therefor the project was carried out in collaboration with the Institute of Pharmaceutical and Biomedical Sciences of Johannes Gutenberg University Mainz. In this study, we investigated the effect of different saccharides as fillers on the

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