Program and book of abstracts 1st conference

October 17 th – 20 th , 2022, Congress Centre of Slovak Academy of Sciences, Smolenice castle, Slovakia

Grepl Pavel

Is a Ph.D. student at the Faculty of Physical Culture, Palacký University Olomouc, Czech Republic. He is working on his Ph.D. in the exercise physiology field and his main research interests include the effect of age on autonomic cardiac regulation. He is part of the successful team from Olomouc which has already published a couple of highly evaluated scientific articles dealing with molecular hydrogen across different conditions. He is currently working on research that evaluates the effect of molecular hydrogen inhalation on selected physiological characteristics. EFFECTS OF MOLECULAR HYDROGEN INHALATION ON AUTONOMIC NERVOUS SYSTEM Pavel Grepl, Michal Botek, Jakub Krejčí Department of Natural Sciences in Kinanthropology, Faculty of Physical Culture, Palacký University Olomouc, Olomouc, Czech Republic BACKGROUND: Evaluating autonomic nervous system (ANS) activity is a very sensitive indicator of changes in the homeostasis of the organism, which were caused by external or internal stressful stimuli. ANS activity is assessed noninvasively through heart rate variability (HRV) monitoring. Administration of molecular hydrogen has been successfully experimentally tested as supportive therapy in various types of clinical diseases including metabolic, neurodegenerative, cardiovascular, and respiratory. Monthly consumption of hydrogenated water (HRW) resulted in decreased sympathetic activity in patients, while acute consumption of 1260 ml of HRW in healthy women resulted in a relative increase in sympathetic activity, with increased vagal activity seen in both HRW and placebo. The impact of the intake of molecular hydrogen by inhalation has not yet been investigated in this regard. OBJECTIVES: The study aims to determine what effect 60 min of H2 inhalation will have on the response of autonomic cardiac regulation during a 45-min post-inhalation session. METHODS:The researchwas conducted as a randomized, double-blind, placebo-controlled, cross-over study. Twelve physically active women (20–26 years old) participated in this study. Subjects underwent 60 minutes of inhalation of molecular hydrogen or placebo. During inhalation, their ventilation parameters were measured. HRV and oxygen saturation were also measured, and their measurement continued 45 minutes after the end of inhalation. Blood pressure was measured before and after each phase. RESULTS: Will be presented in the form of a poster after evaluation. CONCLUSIONS: Will be presented in the form of a poster after evaluation. This work was supported by grant IGA_FTK_2022_013 from Palacký University Olomouc entitled: “ Effect of molecular hydrogen inhalation on the autonomic nervous system (ANS).”

89