Program and book of abstracts 1st conference

October 17 th – 20 th , 2022, Congress Centre of Slovak Academy of Sciences, Smolenice castle, Slovakia

Avan Amir

Dr. Amir Avan is an Associate Professor in Human Genetics. He is Head of Basic Medical Science Institute and Head of Medical Talent Office at MUMS University. His research interest is on introducing novel therapeutic molecules including hydrogen for human diseases especially in cancerous patients. Dr. Avan has been chosen as the Best young inventors in several years, Gold medal in Switzerland among the best innovators and received the Diploma in several national international festivals. Recently he has ranked (academically) among the top 1% researchers, in the world, in the ESI global ranking system, by Essential Science Indicators, 2021 CLARIVATE ANALYTICS. He received an award called “Chris Meijer Award” “Outstanding Scientific Performance” in 2013. His lab has published more than 385 manuscripts in prestigious journals which can be found in the link below: https://pubmed.ncbi.nlm.nih.gov/?term=avan+a&sort=date&size=200 HYDROGEN, A NOVEL THERAPEUTIC MOLECULE, REGULATES OXIDATIVE STRESS AND APOPTOSIS IN MUSCLE ATROPHY OF MICE DURING RECOVERY PHASES A. Avan 1 , F. Babaie 2 , G. A. Ferns 3 1 Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran, 2 Department of Medical Physiology, Mashhad University of Medical Sciences, Mashhad, Iran. 3 Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, BN1 9PH, UK. BACKGROUND: Hydrogenmolecule (H2) is a novel antioxidant withpromising therapeutic properties for muscular diseases. Regulation of oxidative stress is a key factor for attenuating muscular atrophy during acute and recovery phases. OBJECTIVE:This study investigated therapeutic potentials of hydrogenmolecule by regulating apoptosis and oxidant-antioxidant balance during recovery phase of muscular atrophy. METHOD: Expression of apoptotic genes were compared between H2-treated and un treated groups in immobilized muscles in mice. Activation of NFKB signaling pathway was also evaluated in these groups. Concentrations of oxidative stress markers including Malondialdehyde (MDA) and Nitrite were measured in both muscular atrophy tissues and serum in mice. RESULTS: Our result showed that activity of NFKB signaling pathway is significantly regulated in H2-treated group during recovery phase of muscular atrophy. This leads to modulation of down-stream anti-apoptotic genes including BAX and Beclin-1 in muscular tissue samples of H2-treated mice. Next, we found that local as well as circulating concentrations of MDA and Nitrite were potently regulated in H2-treated mice in muscular atrophy. CONCLUSION: We report for the first time that therapeutic potency of H2 during recovery phase of muscular atrophy is mediated through anti-apoptotic and anti-oxidant properties of hydrogen molecule. More selected research based on coordinated multidisciplinary studies is needed to candidate hydrogen molecules for improving muscular atrophy in patients. This work was supported by grants awarded by National Science Foundation to A. A.

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