Program and book of abstracts 1st conference

October 17 th – 20 th , 2022, Congress Centre of Slovak Academy of Sciences, Smolenice castle, Slovakia

Singh Ram B.

Prof Dr Ram B Singh, MBBS, MD(Int.Medi-Cardiol), DTNH, Certified Nutrition Specialist(USA), Halberg Hospital and Research Institute, Civil Lines, Moradabad-10(UP)244001, India. International Expert in Neuro-Cardiology, Chronobiology and Nutraceuticals, antioxidants (Regenerative Medicine). 1.Editor, World Heart Journal, www.novapublishers.com (USA) and 2.Hon. Fellow, Halberg Chronobiology Centre, University of Minnesota, Minneapolis, USA. 3. (Contributed > 650 research papers in peer reviewed journals),18,510, Citations. Edited 7 books by Elsevier,USA and Nova, USA

CAN MOLECULAR HYDROGEN THERAPY ENHANCE OXYGEN SATURATION AMONG PATIENTS WITH CHRONIC LUNG DISEASE? Ram B Singh 1 , AK Gupta 2 , Ghizal Fatima 3 , Jan Fedacko 4 , ViliamMojto 5 . 1,2 Halberg Hospital and Research Institute, Moradabad, India; 3 Era Medical College, Lucknow, India; 4 PJ Safarik University, Kosice, Slovakia; 5Comenius University, Bratislava, Slovakia. BACKGROUND: COVID-19 may be associated with pneumonia, in conjunction withmarked inflammation and oxidative stress which leads to fibrosis in the lungs with respiratory failure. OBJECTIVES: This study aims to emphasize that hydrogen rich water therapy may enhance oxygen saturation among patients with chronic lung diseases and respiratory failure. SUBJECTS AND METHODS: Chronic lung diseases such as bronchial asthma and chronic obstructive pulmonary diseases (COPD) as well as post COVID-19 pulmonary fibrosis may be associated with lung damage along with fibrosis and emphysema. These are major causes of respiratory failure and subsequent hypoxia, which has lethal consequences. Accordingly, new therapies for this disease that reduce hypoxia are urgently needed. It is hypothesized that molecular hydrogen (H2) therapy may decrease inflammation and oxidative stress and reduce hypoxia. A case report published earlier suggests that supplementation with hydrogen-rich water (HRW) increases oxygen saturation up to 45 minutes after its administration in a patient with COVID-19-like symptoms. We also found that treatment withHRWin other patients with chronic lung diseases(n=11) with hypoxia (O2 saturation <95 %) was beneficial in improving oxygen saturation in majority of the patients. Administration of HRW to these patients for 4 weeks was associated with significant increase in oxygen saturation and decrease in TBARS, MDAwith increase in vitaminA, E and C levels. We also report that physical training done after HRW therapy appears to increase exercise tolerance, which decreases hypoxia and delays the need for oxygen therapy. These preliminary findings indicate that HRW supplementation may increase the level of oxygen saturation in patients with COVID-19-like symptoms and those with other chronic lung diseases. HRW therapy may also provide increased exercise tolerance in patients with chronic hypoxia. Recently, molecular hydrogen (H 2 ) has been suggested for the treatment of COVID-19, due to its potential antioxidant and anti-inflammatory effects. It is hypothesized that H 2 therapy may decrease inflammation by reducing free radical-induced damage, which may decrease hypoxia and delay the need for oxygen therapy. This hypothesis has led to the initiation of a large-scale multicenter trial in Europe utilizing hydrogen-producing tablets in high-risk patients undergoing ambulatory care (1-4). KEYWORDS: Antioxidant, free radical stress, inflammation, hydrogen-rich water, post COVID-19

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