Program and book of abstracts 1st conference

1 st Conference of European Academy for Molecular Hydrogen Research in Biomedicine “Hydrogen for Biomedicine“

Shogenova Lyudmila

Dr. Shogenova is an associate professor at the Department of Hospital Therapy, Faculty of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, Moscow. She specializes in anesthesiology and resuscitation. Her PhD thesis was titled "The efficacy of heliox in the treatment of acute respiratory failure in patients with obstructive pulmonary disease". Dr. Shogenova's research interests include using medical gases (hydrogen, heliox and nitric oxide) in the treatment of critically ill patients with signs of respiratory failure. She is the author of more than 45 articles focusing on the effectiveness of medical gases (hydrogen, heliox and nitric oxide) in treating

cardiorespiratory diseases, COVID-19, and post-COVID-19 syndrome. HYDROGEN INHALATION IN REHABILITATION PROGRAM OF THE MEDICAL STAFF, RECOVED AFTER COVID-19 INFECTION THE AIM: To investigate safety and efficiency of active form of hydrogen (AFH, (H(H2O) m)) for rehabilitation of medical staff of Pletnev’s Hospital who had an SARS-CoV-2 infection fromMay to November 2020. MATERIALS AND METHODS: A comparative, parallel, prospective study included 60 patients (medical staff of the D.D. Moscow Pletnev’s Hospital) who underwent COVID-19 fromMay to November 2020. The patients were divided into 2 groups. The 1st group (n-30) included patients who were inhaled an active form of hydrogen for 90 minutes every day during 10 days (apparatus "SUISONIA") with standard protocol treatment for patients who have undergone COVID-19 during the rehabilitation period; group 2 (n-30) - patients who received standard therapy in accordance with the clinical guidelines of theMinistry of Health of the Russian Federation. In the 1st group, the ratio of men / women is 5/25, and in the 2nd group - 4/26, respectively. Both groups were comparable by sex, p - 0, 407 (Fisher's exact test). The mean age of patients was 53.5 years (45 years; 61 years): in the 1st group - 52.73 years old (45 years old; 59.5 years old), in the 2nd group 51.32 years old (36 years old; 70 years old). All patients at baseline and 10 days after the end of the study were assessed for: respiratory rate, heart rate, blood pressure; results of lung computed tomography, echocardiography, plethysmography, spirometry, bodyplethysmography, pulse oximetry, 6-minute walking test, arterial blood gases, venous blood gases and capillary blood gases, complete blood count and biochemical blood tests, coagulogram. RESULTS: When comparing the parameters measured at the beginning of the study and after the finishing of a 10-day cycle of AFH ((H(H2O)m) ) inhalations (for group 1 patients) and standard therapy (for group 2), a decrease of the rigidity index (SI) from 8.2±0.5 to 6.4±0.45 (p≤0.0001), of venous blood lactate from 2.5±0.03 mmol/l to 1.5±0.03 mmol/l (p≤0.01), capillary blood lactate from 2.8±0.05 mmol/L to 2.1±0.04 mmol/L (p≤0.0001), capillary blood carbon dioxide (PcCO2) with 43.3±0.04 mmHg. 42.3±0.05 mm (p≤0.01), the calculated index of the pulmonary shunt (QS/Qt), calculated by Berggren equation, 1942) from 12.8±0.5 to 4.5±0.08 (p≤0.05), were observed. An increase in the reflection index (RI), from 45.3±0.12% to 60.5±0.18% (p≤0.0001), the index of minimum pulse oximetry during

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