Program and book of abstracts 1st conference

1 st Conference of European Academy for Molecular Hydrogen Research in Biomedicine “Hydrogen for Biomedicine“

Noda Mami

Dr. Mami Noda got her PhD in Kyoto University, Japan, and started as a post doc in the Rockefeller University, USA. She used to work in Kyushu University, Japan, working in the field of pathophysiology and pharmacology of the central nervous system. Currently, is an adjunct professor of Xi’an Jiaotong University School of Life Science and Technology, China. Her research interest is how hydrogen gas exerts neuroprotection and resistance to reactive oxygen species (ROS)-related damages in many kinds of cells and organs in our body. The goal of her research is to elucidate the mechanism how hydrogen gas works as effective medical gas. The basic research will contribute to further clinical studies and more evidence, allowing hydrogen gas admitted as a registeredmedical gas and consequently preventing onset of various ROS-related disorders. To prove “slow-aging” effect by hydrogen gas is also her future goal. MODULATION OF ENDOCRINE SYSTEM BY HYDROGEN GAS Mami Noda 1 , Eugene Iv. Nazarov 2 1 School of Life Science, Graduate School of Xi'an Jiaotong University, Xi’an, China 2 Scientific Department of the International Association of Therapists Using Medical Gases, Odessa, Ukraine BACKGROUND: Among many medical gases, ozone (O 3 ), molecular hydrogen (H 2 ), and noble gase Xe seem to relate to endocrine system in common.With repeated administration of the gases over time, the modulations by these 3 gases become a predictable consequence of conditioned homeostatic reflexes, resulting in regulation of physiological activity. OBJECTIVES: This study aimed to assess the effect of H 2 on the endocrine system, partly comparing with the effects by O 3 and Xe. METHODS: Some animal studies and experiments on cellular level were performed. RESULTS: H 2 affects hypothalamic-pituitary-axes like O 3 and Xe. H 2 also affects stomach brain connection, producing and releasing a gastrointestinal hormone, ghrelin. CONCLUSIONS: Drinking H 2 upregulates the release of ghrelin in young mice. H 2 is also reported to attenuate the decline of estrogen in aged female Alzheimer’s disease model mice. Inhaling H 2 -O 2 mixture is reported to inhibit the hypothalamic-pituitary-adrenals (HPA)-axis and inflammatory responses to stress. The mechanism of how H 2 modulates endocrine systems and the fundamental question of what or where is the target of H 2 needs to be elucidated for a better understanding of the effects of H 2 . This work was partly supported by Econika Medical Engineering and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science. Genetics and Molecular Biology by Elsevier consecutively for 8 years (2014-2021) and the World Top 1.5% Scientist (2019-2022).

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