Program and book of abstracts 1st conference

1 st Conference of European Academy for Molecular Hydrogen Research in Biomedicine “Hydrogen for Biomedicine“

Nazarov Eugeny

President of Ukrainean association of ozonetherapy. Chairman of the Steering Committee of the International Association of Medical Gas Therapists. CEO of SPE "Econika Medical Engineering”. Private company dedicated to Medical and physicochemical equipment design and manufacturing. Professor consultant of International Scientific Committee of Ozonetherapy (ISCO3). Research of the mechanism of action of drugs, working out of methods of medicinal therapy, including methods of ozonetherapy. The author 81 scientific articles on biophysics and medical problems. Specialties: Research of the mechanism of physiological activity complexions and their analogues. Research of biophysical mechanisms of action of ozone on biological membranes. Researches in area creation of methods of an estimation of physiological efficiency of ozone, hydrogen and xenon therapy. EXPERIENCE IN THE USE OF MOLECULAR HYDROGEN AND A MIXTURE OF HYDROGEN-NITRIC OXIDE IN HEART SURGERY UNDER CONDITIONS OF ARTIFICIAL BLOOD CIRCULATION Yu.D.Brichkin 1 , A.V.Deryugina 2 , V. V. Pichugin 2 , M.V. Ryazanov 2 , E. I.Nazarov 3 1 .SPECIALIZED CARDIAC SURGERY CLINICAL HOSPITAL.BY NAME ACADEMICIAN B.A. KOROLEV (NIZHNY NOVGOROD), 2 .VOLGA RESEARCH MEDICAL UNIVERSITY BY NAME N.I. LOBACHEVSKY, 3 .SPE ECONIKA, ODESSA The effect of H2 and NO on the parameters of the functional activity of the myocardium and erythrocytes of patients in the postoperative period during the surgical treatment of acquired heart valve defects investigated. It was shown that the level of selective indicator of myocardial damage Troponin 1, decreases in the NO and NO+H2 groups by 1.5 and 2.6 times compared with the control group 24 hours after the operation. Two days after the operation, the average level of Troponin 1 in the NO+H2 group was equal to the upper limit of the physiological norm. It has been suggested that the mechanism of the combined action of a mixture of nitric oxide and hydrogen lies in the synergistic effect of the vasodilating action of NO and the reduction of peroxynitrite levels by hydrogen, caused by the action of exogenous NO. This work is a development of our research cycle on the use of medical gases in the surgical treatment of acquired valvular defects using cardiopulmonary bypass (CB). This study examined the comparative effectiveness of nitric oxide (NO) and hydrogen (H2) on the state of erythrocytes and functional parameters of cardiac activity in patients of two experimental groups and one control group with a total of 88 patients. The gas mixture introduced into the CB circuit consisted of: 0.25 l/min NO + 2 l/min O2 for the first experimental group (33patients), 0.25 l/minNO+0.12 l/minH2+2 l/minO2 for the second experimental group (25 patients ) and 2 L/min O2 for the control group (30 patients). The sources of NO and H2 were the TIANOKS (Sarov) and Bozon H2/O3 (Odessa) devices. The influence of these medical gases was assessed by the dynamics of Troponin I activity,

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