Program and book of abstracts 1st conference

October 17 th – 20 th , 2022, Congress Centre of Slovak Academy of Sciences, Smolenice castle, Slovakia

Ghizal Fatima EFFECTS OF MOLECULAR HYDROGEN THERAPY ON CIRCADIAN BLOOD PRESSURE VARIABILITY. NOTABLY AT NIGHT Ram B Singh, Ghizal Fatima, Aminat Magamedova, JP Sharma, Divyank Sharma 1 Halberg Hospital and Research Institute, Moradabad, India, Era Medical College, Ghizal Fatima, 4 Lomosonov Moscow State University, Moscow, Russia. BACKGROUND: The earth revolves around its axis, causing the light and dark cycles of 24-Hours. resulting in to day and night. These rotations of the planet are associated with alteration in physiological functions which vary according to time structure of 24 hours. OBJECTIVES: This study aims to emphasize that molecular hydrogen therapy in patients with circadian increase of blood pressure (BP) may reverse Covid-19 induced loss of dipping. METHODS ANDRESULTS: Adverse effects of high blood pressure (BP) on the heart correlate better with 24-hour means of BP than with casual BP readings, to which nocturnal BP, and morning rise inBP, plays aparticularly important role [8-10].Under usual conditions, nighttime BP is typically lower than daytime BP. Elevated nocturnal BP (nocturnal hypertension) and disrupted circadian variation in BP emerged as independent risk factors for cardiovascular disease (CVD) and all-cause mortality. Variability in BP and HR stem from an endogenous circadian rhythm, which persists under constant conditions, and from a host of external factors, including an influence from space weather and climate. Determinants of the circadian rhythm in BP are still poorly understood. It is not well known whether they are similar or different during the day or night and how that may interact with sleep and night shift work. Night shift work is known to cause sleep disturbance, increase in night time BP along with oxidative stress and inflammation due to increase in cortisol and decrease in melatonin. While hypertensive patients with COVID-19 appear to have a poor prognosis, there is no evidence that hypertension increases the risk of new infection or adverse outcomes independent of age and other risk factors. It has been suggested, however, that hypertension and BP variability are exacerbated by acute SARS-CoV-2 immune reactions, that has been observed in a male physician, 77 years of age, presenting with COVID-19 in 2021. He had severe insomnia and increase in night-time blood pressure (BP) as shown by self-recorded data. Supplementation with hydrogen-rich water (HRW) increased oxygen saturation 10- 45 minutes after its administration in a patient with COVID-19-like symptoms. We also found that treatment with HRW in other patients with night shift work (n=9) with nocturnal rise in BP (BP >110/75 mm Hg) was beneficial in improving nocturnal increase in BP (loss of dipping) in majority of the patients. There was a significant increase in melatonin and a decrease in cortisol among these patients. After a week, BP measurements showed that BP was reduced, notably at night. Systolic(S) and diastolic(D) BP, which averaged 127.2/84.9 mmHg in April, decreased to 113.5/79.5 mmHg in June (P<0.001). It doubled in the case of SBP and DBP and increased by 85% in the case of heart rate (HR). The difference between daytime (09:00 and 13:00) and night-time (02:30 and 05:30) measurements also increased between April and June: from 1.8

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