Program and book of abstracts 1st conference

1 st Conference of European Academy for Molecular Hydrogen Research in Biomedicine “Hydrogen for Biomedicine“

Firment Jozef

Dr. Firment is an associate professor of PJ Šafárik University in Košice. He works as the head of Department of Anaesthesiology and Intensive Care Medicine at the University Hospital. He is currently a member of a research team interested in the implementation of advanced pulmonary ventilation methods for the treatment of severe pneumonia. His publications are on the diagnosis and treatment of sepsis and septic shock and on the monitoring of critically ill patients. THE BENEFICIAL EFECT OF MOLECULAR HYDROGEN IN INTENSIVE CARE IS AWAITED J. Firment, J. Capková, J. Simonova, V. Hudak, M. Grochova Department of Anaesthesiology & Intensive Care Medicine, L. Pasteur University Hospital, Faculty of Medicine PJ Šafárik University in Košice, Slovak Republic CONCLUSIONS: Hydrogen therapy is shown to be effective and promising in the treatment of multiple organ failure syndrome (MODS). Clinical and experimental studies suggest that hydrogen therapy may provide benefits in the treatment of postresuscitation syndrome and other ischemia-reperfusion injuries, stage IV colorectal cancer, stroke, dyslipidaemia, endothelial dysfunction, atherosclerosis. Treatment withH2 can also bemediated by probiotics. At the authors' workplace, there is anH2 generator AMS-H-03 formedical use, which produces by electrolysis H2 66% : O2 33% with a production of 2-3 l H2/min. The gaseous form of H2 can be applied through a nebulizer with a nasal catheter or connected to the inspiratory branch of the ventilator. The created HRW can be used to produce sterile HRS in a plastic bag. Questions to be answered: a) How to avoid the risk of explosion? b) How to determine the administration technique taking into account H2 leakage from the bottles and through the walls of the hoses? c) To verify the effectiveness of 2% concentration of H2 in the inspiratory mixture. d) To determine the dosage of H2 in specific indications for critically ill patients. e) What are the expected adverse effects of hydrogen administration? Are we endangering the natural inflammatory processes of the tissue's defence reaction? The pleiotropic effects of molecular hydrogen on various proteins, molecules, and signalling pathways may at least partially explain its near-universal pluripotent therapeutic potential. Intensive negotiations are currently underway aimed at registering the use of molecular hydrogen for medical purposes in the Czech Republic, and we expect a change in legislation in the Slovak Republic as well. This publication is the result of the project implementation: „Design and implementation of advanced methods of lungs ventilation treatment and diagnosis of viral pneumonia, including Covid-19 with the possibility of their rapid adoption“, ITMS2014+: 313011ASX1 supported by the Operational Programme Integrated Infrastructure, funded by the ERDF.

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