Program and book of abstracts 1st conference

1 st Conference of European Academy for Molecular Hydrogen Research in Biomedicine “Hydrogen for Biomedicine“

Saman Ezgi NITRIC OXIDE-DEPENDENT PATHWAY IN METABOLIC SYNDROME: POSSIBLE INTERACTIONS WITH MOLECULAR HYDROGEN Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia BACKGROUND: Metabolic syndrome has been characterized by a clustering of cardiovascular risk factors including obesity, hypertension, insulin resistance, and dyslipidemia which are related to endothelial dysfunction and increased in oxidative load. Under metabolic syndrome conditions, increased levels of free fatty acids levels contribute to the activation of ceramides. Initially, ceramides may activate NADPH-oxidase which results in oxidative stress generation. On the other hand, ceramide leads to diminishing effects on Akt activation.Then, endothelial nitric oxide (eNOS) becomes uncoupled through inhibition of the PI3K-Akt pathway and resulting in reactive oxygen species (ROS) generation in the cell. This leads to increased NF-κB activity followed by eNOS and iNOS upregulation. OBJECTIVES: This study aimed to make an overview of possible antioxidant effects of molecular hydrogen in metabolic syndrome, especially the effect on NO/ROS balance.

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