Book of Abstracts - New Frontiers 2022

Abstracts of oral presentations

EXTRACELLULAR MATRIX REMODELING UNDER PRESSURE OVERLOAD

B. Podesser 1,2 , A. Kiss 1,2 , P. Pokreis 1,2 , L. Szabo 1,2 , C. Dostal 1,2

1 Medical University of Vienna, Austria; 2 Ludwig Boltzmann Institute, Vienna, Austria

Pressure overload has server consequences not only for the cardiomyocytes but also for the extracellular compartment, leading ultimately to fibrosis and functional impairment including heart failure with preserved ejection fraction (HFpEF). During recent years various experimental and clinical studies have describe the process of remodeling at the level of the organ, the cell and the sub cellular compartments and defined the important players in this process of adaptation. In contrast little is known when it comes to unloading the heart- the so call reverse remodeling. We and others have conducted preclinical work that shall give an insight into this process at all three levels, the organ, cell and sub cellular compartment. The presented data will allow to speculate on fundamental principles of remodeling and reverse remodeling, using classic physiological examination combined with modern imaging and molecular biology. Finally, the gained preclinical information with be highlighted with respect to clinical data.

Keywords: remodeling, reverse remodeling, pressure overload

Funding:Ludwig Boltzmann Institute, Vienna, Austria

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