Book of Abstracts - New Frontiers 2022

Abstracts of oral presentations

EVs IN OXIDATIVE STRESS AND CARDIOPROTECTION

Z. Giricz

Department of Pharmacology, Semmelweis University, Budapest, Hungary

Extracellular vesicles (EVs) are actively investigated for their role both in cardiac pathologies involving oxidative stress and in cardioprotective interventions that may alleviate oxidative stress-induced cardiac insults. Although EVs have been the focus of numerous cardiac research projects for decades, their isolation from bodily fluids still poses challenge that may influence results of studies as well as their reproducibility and translatability. Similarly, methods for production of EVs suitable for therapeutic goals and that are potentially applicable in industrial settings have to be developed for cardiovascular medicine. In this lecture recent advances and remaining challenges in the field of EV isolation technologies will be summarized. The presentation will also include novel findings on cardioprotection achieved by EVs in models of ischemic cardiac diseases, and on methods being developed for cardioprotective EV production.

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