Book of Abstracts - New Frontiers 2022

Abstracts of poster presentations

STIMULATION AND UNLOADING OF BARORECEPTORS MODULATE COUGH IN EXPERIMENTAL CONDITIONS

A. Matloobi, T. Buday, M. Konarska, M. Brozmanova, J. Plevkova

Department of Pathological Physiology, Jessenius Faculty of Medicine in Martin, Comenius University, Martin, Slovak Republic

Cough, as the main airway defensive process is modulated by multiple secondary sensory inputs from the respiratory system and outside of it. This modulation is one of the mechanisms that contribute to sensitization of cough related pathways at the peripheral and /or central level via neuroplasticity and it manifests in clinical settings most often as augmented coughing. Some circumstantial and inconsistent findings from the older studies in animal models resulted to more sophisticated studies focusing on both stimulation and unloading of baroreceptors on cough in experimental conditions and computational simulations. These studies confirm that baroreflex alters coughing evoked in experiment even though the evolutional and/or physiological purpose of such regulations, nor clinical relevance of these findings are not understood at the moment.

Keywords: cough, baroreceptors, neurons, animal studies

96